Cis-regulatory elements underlying Prdm15 gene during brain development

TABLE OF CONTENT

ABSTRACT

ACKNOWLEDGEMENTS

DEDICATION

TABLE OF CONTENT

LIST OF FIGURES

CHAPTER ONE
INTRODUCTION

CHAPTER TWO
LITERATURE REVIEW
2.1 Prdm gene family
2.2 Cis -regulatory architecture of the genome
2.3 Transcriptional regulation by enhancers
2.3.1 Transcriptional enhancers
2.3.2 Deregulation of enhancer function in human disease
2.4 Chromatin signatures in different enhancer states
2.4.1 Interaction between transcription factors and chromatin
2.5 Genome wide identification of enhancer element

CHAPTER THREE
MATERIALS AND METHODS
3.1 Search for cis -regulatory element(s) in the vicinity of Prdm15 by comparative genomics
3.2 Delineation of candidate brain enhancers of Prdm15 using brain-specific enhancer chromatin modification signatures

CHAPTER FOUR
RESULTS

CHAPTER FIVE
DISCUSSION

6.1 Conclusions

6.2 Recommendations

REFERENCES