Cis-regulatory elements underlying Prdm15 gene during brain development

Inhaltsverzeichnis (Table of Contents)

• CHAPTER ONE
  • INTRODUCTION
• CHAPTER TWO
  • LITERATURE REVIEW
    • Prdm gene family.
    • Cis-regulatory architecture of the genome.
    • Transcriptional regulation by enhancers
      • Transcriptional enhancers
      • Deregulation of enhancer function in human disease
    • Chromatin signatures in different enhancer states
    • Interaction between transcription factors and chromatin ..
    • Genome wide identification of enhancer element..

Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)

This dissertation investigates the cis-regulatory network underlying the Prdm15 gene during brain development, aiming to identify brain-specific enhancers for this gene. The study utilizes the VISTA enhancer browser and ENCODE data to identify and characterize these enhancers.

• Cis-regulatory elements and their role in gene expression
• The Prdm15 gene and its function in brain development
• Identification and characterization of brain-specific enhancers for Prdm15
• Chromatin modifications associated with enhancer activity
• The potential role of transcription factors in regulating Prdm15 expression

Zusammenfassung der Kapitel (Chapter Summaries)

Chapter One provides an introduction to the research topic, highlighting the importance of understanding the regulatory mechanisms governing gene expression in brain development. Chapter Two delves into the existing literature, reviewing key concepts such as the Prdm gene family, cis-regulatory elements, enhancer function, chromatin modifications, and methods for identifying enhancers. The chapter discusses the significance of understanding enhancer function in both normal development and disease contexts.

Schlüsselwörter (Keywords)

The key themes and concepts explored in this dissertation include cis-regulatory elements, enhancers, Prdm15, brain development, chromatin modifications, transcription factors, and gene regulation. The study specifically focuses on identifying brain-specific enhancers for the Prdm15 gene, contributing to our understanding of the intricate regulatory networks that govern gene expression during this crucial developmental process.