Doktorarbeit / Dissertation, 2020
48 Seiten
1.1 Background of the study
1.2 Problem statement.
1.3 Study objectives
1.3.1 General objective
1.3.2 Specific Objectives
1.4 Research questions
1.5 Conceptual frame
1.6 Significance of the study
1.7 Scope of the study
1.7.1 Geographical Scope
1.7.2 Time Scope
Chapter Two
Literature Review
2.1 Introduction
2.2 Level of uptake of human papilloma vaccine
2.3 The caregiver’s factors
2.4 Health system factors and uptake of HPV vaccine
Chapter Three
Methodology
3.1 Introduction
3.2 Study design.
3.3 Study area
3.4 Sources of data
3.5 Study Population
3.6 Inclusion criteria
3.7 Exclusion criteria.
3.7.1 Sampling method.
3.7.2 Sample size estimation.
3.8 Study variables.
3.8.1. Dependent variable
3.8.2 The independent variables
3.9 Data Collection method
3.10 Data collection tools
3.11 Data management.
3.12 Data analysis plan.
3.13 Ethical considerations
3.14 Dissemination of Results
Chapter Four
Results
Chapter Five
Discussion
Chapter Six
Conclusions And Recommendations.
The primary research objective is to investigate and determine the key factors affecting the uptake of the Human Papilloma Virus (HPV) vaccine among girls aged 9-14 years in the Bukomansimbi Sub-County, Bukomansimbi District, Uganda, to provide actionable data for improving immunization strategy compliance.
1.1 Background of the study
Human papillomavirus (HPV) infection is now a well-established cause of cervical cancer which ranks as the fourth most frequent cancer among women in the World More than 270 000 women die of cervical cancer worldwide every year and over 85% of these deaths occur in low and middle income countries (WHO, 2017).
The latest statistics published by the International Agency for Research on Cancer (IARC), the specialized cancer agency of the World Health Organization, shows that cervical cancer occupies the fourth position in the list of the most common cancers affecting women all over the world, preceded by breast, colorectal, and lung cancers. More specifically, the estimated incidence of cervical cancer was of 527,624 new cases in 2012. In the same year, cervical cancer was responsible for 265,653 deaths in the world, which constituted the fourth most common cause of cancer death worldwide. Cervical cancer is often defined as a disease of disparity, because it differently affects poor and wealthy countries: at least 80% of cervical cancer deaths occur in developing countries. However, disparities also occur within a single country, as is the case of the USA, where Hispanic and African American women have, respectively, 2 and 1.5 times more risk of developing cancer than non-Hispanic White women. In Europe, the incidence and mortality rates of cervical cancer vary considerably within the region. (Victoria F et al, 2015)
Since 2006, two human papillomavirus vaccines (HPVV) have been licensed globally, aimed at preventing cervical cancer: Cervarix, a bivalent vaccine that targets papillomavirus 16 and 18, and Gardasil, which additionally targets papillomavirus 6 and 11. Types 16 and 18 are responsible for around 70% of all cervical cancer cases, whereas types 6 and 11 are responsible for about 90% of anogenital warts. Immunization as a three-dose series against the human papillomavirus (especially before sexual onset) is recommended as primary prevention method of certain HPV infections, in order to reduce the incidence of cervical cancer and other anogenital cancer.
1.1 Background of the study: Provides a global context on cervical cancer and the importance of HPV vaccination as a preventative public health measure.
1.2 Problem statement: Highlights the low uptake of HPV vaccines in Uganda despite established national immunization programs and WHO guidelines.
1.3 Study objectives: Defines the specific goals regarding the determination of vaccine uptake levels and associated determinants in the study area.
1.4 Research questions: Formulates the core inquiries regarding caregiver and health system factors influencing vaccine uptake.
1.5 Conceptual frame: Outlines the dependent and independent variables, including caregiver demographics and health system attributes.
1.6 Significance of the study: Discusses the academic and policy relevance of the research for maternal health promotion in Uganda.
1.7 Scope of the study: Defines the geographical setting of Bukomansimbi Sub-County and the project timeline.
Chapter Two (Literature Review): Reviews scholarly work and global/regional studies on HPV uptake patterns and determinant factors.
Chapter Three (Methodology): Details the study design, sampling techniques, data collection methods, and ethical considerations employed.
Chapter Four (Results): Presents the quantitative findings of the study based on caregiver surveys and statistical analysis.
Chapter Five (Discussion): Interprets the study results by comparing them with existing literature and prior research findings.
Chapter Six (Conclusions And Recommendations): Provides synthesized conclusions and actionable recommendations for health authorities and stakeholders.
HPV, Human Papillomavirus, Cervical Cancer, Vaccination, Immunization, Bukomansimbi, Caregivers, Vaccine Uptake, Public Health, Reproductive Health, Vaccine Hesitancy, Adolescent Health, Health Systems, Preventive Medicine, Socio-demographics
The research focuses on assessing the factors that influence the uptake of HPV vaccination among girls aged 9-14 years within the Bukomansimbi Sub-County in Uganda.
The study covers caregiver knowledge and attitudes, socio-economic status, health system accessibility, vaccine supply, and the influence of school-based immunization programs.
The goal is to identify barriers to full vaccination series completion to help stakeholders improve local immunization strategies and reduce cervical cancer incidence.
The study utilizes a cross-sectional quantitative research design, involving questionnaire-based surveys and statistical analysis (Chi-square and logistic regression).
The main body examines the background of HPV, provides a comprehensive literature review, details the methodology, presents statistical results, and discusses these findings relative to similar global and local studies.
Key characteristics include an emphasis on Bukomansimbi as a case study, a focus on demographic variables like caregiver occupation and education, and an emphasis on the role of community awareness.
The study found that caregivers who express strong beliefs that the vaccine is necessary for preventing cervical cancer are significantly more likely to ensure their daughters complete the required vaccination doses.
Data indicates that proximity is a critical factor; individuals residing within 4km of a health facility demonstrated significantly higher vaccine uptake rates compared to those living in remote or far-reaching localities.
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