Doktorarbeit / Dissertation, 2021
199 Seiten, Note: N/A
This thesis investigates the regulation of stimulus-responsive extracellular vesicle release and its connection to Lewy body disease. It focuses on the role of calcium influx, multivesicular body (MVB) biogenesis, and the impact of basic fibroblast growth factor (bFGF) on exosome release. The work aims to elucidate the underlying mechanisms of exosome secretion and their potential involvement in the propagation of Lewy body pathology.
The introduction provides an overview of Lewy bodies, their association with Parkinson's disease, and the role of extracellular vesicles in their propagation. It also discusses the impact of neurotrophic factors, particularly bFGF, on Lewy body pathology.
Chapter 2 details the methodology, methods, and materials used in the research. This includes descriptions of patch clamp electrophysiology, cell culture techniques, exosome labeling, and the use of bioelectric stimuli.
Chapter 3 presents the research findings. It explores the connection between α-syn expression, exosomal release, and calcium levels. The chapter also investigates the role of growth factors, particularly bFGF, in regulating exosomal release.
The main keywords of this thesis include extracellular vesicles, exosomes, Lewy body disease, Parkinson's disease, α-synuclein, calcium influx, MVB biogenesis, bFGF, SNARE proteins, neurotrophic factors, and cellular signaling pathways. This work examines the interplay between these factors and their influence on exosome secretion and its potential implications for Lewy body pathology.
Der GRIN Verlag hat sich seit 1998 auf die Veröffentlichung akademischer eBooks und Bücher spezialisiert. Der GRIN Verlag steht damit als erstes Unternehmen für User Generated Quality Content. Die Verlagsseiten GRIN.com, Hausarbeiten.de und Diplomarbeiten24 bieten für Hochschullehrer, Absolventen und Studenten die ideale Plattform, wissenschaftliche Texte wie Hausarbeiten, Referate, Bachelorarbeiten, Masterarbeiten, Diplomarbeiten, Dissertationen und wissenschaftliche Aufsätze einem breiten Publikum zu präsentieren.
Kostenfreie Veröffentlichung: Hausarbeit, Bachelorarbeit, Diplomarbeit, Dissertation, Masterarbeit, Interpretation oder Referat jetzt veröffentlichen!
Kommentare