Mapping and DNA sequence analysis of Genes underlying Isolated Autosomal Human Hereditary Alopecia in Pakistani families

Inhaltsverzeichnis (Table of Contents)

• Introduction
  • Alopecia: A Review
  • Isolated Autosomal Human Hereditary Alopecia
  • Objectives
• Materials and Methods
  • Patients and Samples
  • DNA Extraction
  • Genotyping
  • Statistical Analysis
• Results
  • Genetic Linkage Analysis
  • DNA Sequence Analysis
  • Identification of Novel Mutations
• Discussion
  • Genetic Basis of Alopecia
  • Implications for Diagnosis and Treatment
  • Future Directions

Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)

This dissertation investigates the genetic basis of Isolated Autosomal Human Hereditary Alopecia (IAHHA) in Pakistani families. The study aimed to identify genes responsible for IAHHA and analyze their DNA sequences to uncover the genetic mutations underlying this condition.

• Genetic Mapping and Linkage Analysis
• DNA Sequence Analysis of Candidate Genes
• Identification and Characterization of Novel Mutations
• Understanding the Genetic Basis of IAHHA
• Potential Implications for Diagnosis and Treatment

Zusammenfassung der Kapitel (Chapter Summaries)

The introduction provides a comprehensive overview of alopecia, focusing on IAHHA and its genetic basis. It outlines the objectives of the study, highlighting the specific goals of identifying genes associated with IAHHA and analyzing their DNA sequences.

The materials and methods chapter details the methodology employed in the research. This includes the recruitment of patients, DNA extraction techniques, genotyping procedures, and statistical analysis methods used to identify genetic linkage and analyze DNA sequences.

The results chapter presents the findings of the genetic linkage analysis and DNA sequence analysis. It describes the identification of candidate genes associated with IAHHA and the novel mutations identified in their sequences.

The discussion chapter analyzes the results and interprets their significance. It discusses the implications of the findings for understanding the genetic basis of IAHHA, its potential applications for diagnosis and treatment, and future directions for research.

Schlüsselwörter (Keywords)

The main keywords and focus topics of this dissertation include: Isolated Autosomal Human Hereditary Alopecia (IAHHA), genetic mapping, linkage analysis, DNA sequence analysis, gene mutations, Pakistani families, genetic basis of alopecia, diagnosis, treatment, future research.