Clinicopathologic pattern and DNA methylation status of colorectal carcinoma in a group of Bangladeshi patients

Inhaltsverzeichnis (Table of Contents)

• INTRODUCTION
• REVIEW OF LITERATURE
  • Anatomical consideration
  • Physiology
  • Tumors of the colon and rectum
• MATERIALS AND METHODS
• OBSERVATIONS AND RESULTS
• DISCUSSION
• SUMMARY AND CONCLUSION
• BIBLIOGRAPHY
• APPENDICES

Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)

This study aims to investigate the clinicopathologic pattern and DNA methylation status of colorectal carcinoma (CRC) in a group of Bangladeshi patients. The study aims to analyze the prevalence and characteristics of CRC in this population and explore the role of DNA methylation in the development and progression of the disease.

• Clinicopathologic characteristics of colorectal cancer in Bangladeshi patients
• Analysis of DNA methylation status in CRC cases
• Correlation of methylation status with clinical and pathological features
• Potential implications of methylation findings for diagnosis and treatment
• Comparison of findings with previous studies in other populations

Zusammenfassung der Kapitel (Chapter Summaries)

• Introduction: Provides an overview of colorectal cancer (CRC), including its global prevalence, risk factors, and challenges in early detection. It highlights the limited data on CRC in Bangladesh and emphasizes the need for further research in this context.
• Review of Literature: Discusses the anatomical and physiological aspects of the colon and rectum, emphasizing the specific features of CRC, its pathogenesis, and existing knowledge on DNA methylation in cancer development.
• Materials and Methods: Outlines the methods employed in the study, including the patient selection criteria, collection of clinical and pathological data, DNA extraction and methylation analysis techniques.
• Observations and Results: Presents the study findings regarding the clinicopathologic characteristics of CRC cases, including demographics, tumor location, histopathology, and DNA methylation patterns.
• Discussion: Interprets the results in relation to existing literature, highlighting the similarities and differences observed in the Bangladeshi population. It discusses the potential implications of the study findings for clinical practice and future research directions.

Schlüsselwörter (Keywords)

This study focuses on the clinical and molecular aspects of colorectal cancer (CRC) in Bangladesh. It explores the clinicopathologic pattern, DNA methylation status, and potential associations with tumor characteristics. The study utilizes various methodologies including histopathological analysis, immunohistochemistry, and DNA methylation profiling.