Molecular Evolution of Pyroglutamylated RFamide Peptide and Orphan G Protein Coupled Receptor

Inhaltsverzeichnis (Table of Contents)

• G PROTEIN COUPLED RECEPTORS
• G-PROTEINS
• RFAMIDE NEUROPEPTIDE FAMILY AND 26-AMINO ACID RESIDUE RFAMIDE PEPTIDE (26RFA/QRFP)
• PYROGLUTAMYLATED RFAMIDE PEPTIDE RECEPTOR
• SURPRISES FROM THE FASCINATING RESEARCH ON QRFP AND ITS RECEPTORS
• CONCLUSIONS AND FUTURE DIRECTIONS

Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)

This monograph aims to provide a comprehensive exploration of the molecular evolution of pyroglutamylated RFamide peptide and its orphan G protein coupled receptor (GPR103). The work delves into the evolutionary history of these molecules, highlighting their significance in various biological processes.

• The molecular evolution of G protein-coupled receptors (GPCRs) and G-proteins.
• The evolutionary history of the RFamide neuropeptide family, specifically focusing on the 26-amino acid residue RFamide peptide (26RFA/QRFP).
• The molecular evolution of the pyroglutamylated RFamide peptide receptor (QRFPR) and its functional implications.
• The role of natural selection in the evolution of QRFPRs across different species.
• The recent findings regarding the function and role of QRFP and its receptor in regulating biological processes.

Zusammenfassung der Kapitel (Chapter Summaries)

• Introduction: This chapter introduces the concept of molecular evolution, outlining its importance in understanding the diversity of life on Earth. It also discusses the historical development of molecular biology and its impact on the study of evolution.
• G PROTEIN COUPLED RECEPTORS: This chapter provides a detailed overview of G protein-coupled receptors (GPCRs), their structure, and their essential roles in cell signaling and communication.
• G-PROTEINS: This chapter focuses on G-proteins, their structure, and their interaction with GPCRs in mediating cellular responses to various stimuli.
• RFAMIDE NEUROPEPTIDE FAMILY AND 26-AMINO ACID RESIDUE RFAMIDE PEPTIDE (26RFA/QRFP): This chapter explores the RFamide neuropeptide family, highlighting the 26-amino acid residue RFamide peptide (26RFA/QRFP) and its involvement in neuroendocrine and behavioral functions.
• PYROGLUTAMYLATED RFAMIDE PEPTIDE RECEPTOR: This chapter delves into the molecular evolution of the pyroglutamylated RFamide peptide receptor (QRFPR), examining its phylogeny and functional implications. It also analyzes the impact of natural selection on its evolution.

Schlüsselwörter (Keywords)

The key terms and concepts explored in this monograph include molecular evolution, G protein-coupled receptors (GPCRs), G-proteins, RFamide peptides, 26RFA/QRFP, pyroglutamylated RFamide peptide receptor (QRFPR), phylogeny, natural selection, functional implications, neuroendocrine function, behavioral function, and the role of QRFP and its receptor in biological processes.