Doktorarbeit / Dissertation, 2014
122 Seiten
This thesis aims to investigate the antioxidant and cytoprotective properties of flavonoids extracted from the bark of Semecarpus anacardium. The research explores the mechanisms by which these flavonoids combat oxidative stress and their potential therapeutic applications.
Chapter I: Introduction and Review of Literature: This chapter provides a comprehensive overview of oxidative stress, its contribution to various pathologies, and the body's natural defense mechanisms. It details the roles of reactive oxygen species (ROS) like hydrogen peroxide and superoxide, emphasizing their involvement in cellular damage and disease progression. The chapter extensively reviews the functions of key antioxidant enzymes, such as superoxide dismutase (SOD) and catalase, and their synergistic actions in mitigating ROS-induced harm. Furthermore, it highlights the importance of flavonoids, a class of natural antioxidants, in scavenging free radicals and protecting against oxidative stress. The discussion extends to the role of the Nrf2 transcription factor in regulating the expression of cytoprotective genes, underscoring its significance in maintaining cellular homeostasis. Finally, the chapter touches upon the historical and ongoing use of medicinal plants, particularly in traditional medicine systems, as sources of valuable therapeutic compounds.
Oxidative stress, Reactive Oxygen Species (ROS), Antioxidant enzymes, Superoxide dismutase (SOD), Catalase, Flavonoids, Semecarpus anacardium, Nrf2, Cytoprotection, Medicinal plants.
This thesis investigates the antioxidant and cytoprotective properties of flavonoids extracted from the bark of Semecarpus anacardium and explores their mechanisms in combating oxidative stress and potential therapeutic applications.
Key themes include oxidative stress and its role in diseases, antioxidant enzymes (SOD, catalase) and their mechanisms, flavonoids as antioxidants and their mechanisms of action, the role of Nrf2 in cytoprotection, and medicinal plants and their traditional uses.
Chapter I provides a comprehensive overview of oxidative stress, its contribution to various pathologies, and the body's natural defense mechanisms. It details the roles of reactive oxygen species (ROS), antioxidant enzymes (SOD, catalase), flavonoids, and the Nrf2 transcription factor. It also touches upon the historical and ongoing use of medicinal plants in traditional medicine.
The research aims to investigate the antioxidant and cytoprotective properties of flavonoids from Semecarpus anacardium bark, exploring their mechanisms in combating oxidative stress and their potential therapeutic applications.
Key words include Oxidative stress, Reactive Oxygen Species (ROS), Antioxidant enzymes, Superoxide dismutase (SOD), Catalase, Flavonoids, Semecarpus anacardium, Nrf2, Cytoprotection, and Medicinal plants.
This comprehensive language preview includes the title, table of contents, objectives and key themes, chapter summaries, and key words.
The provided preview only shows the first chapter, "Chapter I: Introduction and Review of Literature," which is further divided into sections 1.1 Introduction and 1.2 Review of Literature.
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