Masterarbeit, 2001
173 Seiten
This thesis examines the relationship between tumour necrosis factor-alpha (TNF-α) and weight loss in patients with chronic obstructive pulmonary diseases (COPD). The study aims to assess the prevalence of malnutrition in COPD patients and its adverse effects, explore the role of TNF-α in the pathogenesis of weight loss, and evaluate the effectiveness of nutritional interventions in improving nutritional status and clinical outcomes.
Chronic obstructive pulmonary disease (COPD), malnutrition, weight loss, tumour necrosis factor-alpha (TNF-α), nutritional assessment, nutritional interventions, inflammatory cytokines, clinical outcomes.
Weight loss, especially the loss of fat-free mass, is common in COPD patients and is an unfavorable prognostic factor for survival and quality of life.
Tumour necrosis factor-alpha (TNF-α) is an inflammatory marker. High levels are associated with a systemic inflammatory response and cachexia (severe weight loss) in COPD patients.
While increased energy expenditure is a factor, systemic inflammation and mediators like TNF-alpha are believed to play a significant role in malnutrition and muscle wasting.
Assessment includes anthropometric measurements, evaluating somatic and visceral proteins, and measuring markers of inflammation like serum TNF-alpha levels.
Yes, management strategies aimed at increasing energy balance can help malnourished patients increase their weight and fat-free mass, improving physical performance.
Malnutrition negatively impacts the respiratory system, contributing to increased morbidity, mortality, and reduced quality of life in chronic lung diseases.
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