Effect of APOE4 genotype and Alzheimer’s-related cerebrospinal fluid markers on cognitive decline in non-demented elderly

Inhaltsverzeichnis (Table of Contents)

• Abstract
• Introduction
• Materials and Methods
• Results
• Discussion
• Conclusion
• References
• Appendix

Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)

This study investigates the correlation between the APOE4 genotype, cerebrospinal fluid (CSF) markers indicative of Alzheimer's disease (AD) pathology, and cognitive decline in non-demented elderly individuals. The study aims to determine if these factors can be used to predict future cognitive decline.

• The relationship between APOE4 genotype and cognitive function
• The role of CSF Aβ and tau levels in predicting cognitive decline
• The impact of age and sex on CSF markers and cognitive performance
• The limitations of current AD research and the need for further investigation
• The potential of CSF biomarkers for early detection and prevention of AD

Zusammenfassung der Kapitel (Chapter Summaries)

• Abstract: This chapter summarizes the study's aims, methods, results, and conclusions. It highlights the need for early detection and prevention of AD and the potential role of APOE4 genotype and CSF biomarkers.
• Introduction: This chapter provides an overview of AD, its prevalence, and the challenges of current treatment options. It discusses the role of the APOE4 gene and CSF markers in AD pathology, emphasizing the need for early detection.
• Materials and Methods: This chapter describes the study participants, the cognitive testing procedures, and the methods used to measure CSF markers and APOE4 genotype.
• Results: This chapter presents the findings of the study, including the relationship between age, APOE4 genotype, CSF markers, and cognitive performance.

Schlüsselwörter (Keywords)

Alzheimer's disease, APOE4, cerebrospinal fluid, cognitive decline, mnemonic discrimination, Aβ, tau, biomarkers, early detection, prevention.