Natural Iron Chelator. Chemistry, Biology, and Therapeutic Applications

Table of Contents

• I. Introduction
  • Iron disorders in the human body
  • Natural compounds as alternative chelating agents
  • Agricultural wastes with reported iron chelating activity
  • Chemical and biological activity of Mangifera Indica L. leaves
  • Iron chelation assays
• II. Phytochemical screening and iron chelating activity of Mangifera indica L. leaves
• III. Bio-guided fractionation of iron chelators from Mangifera indica L. leaves
  • Identification of the isolated compounds
• IV. A comparative study of the iron chelating property of mangiferin Vs. desferal®
• V. In-vivo investigation of the total extract (TM) and the ethyl acetate fraction (EM) of Mangifera indica L. leaves in iron overloaded rats

Objectives and Key Themes

The main objective of this work is to explore agricultural residues rich in polyphenolic compounds for their iron chelating activity, to isolate and evaluate these compounds as potential natural iron chelators, and to compare their efficacy to commercially available iron chelators. The study aims to identify and evaluate the most effective iron chelator from agricultural wastes through a series of steps, including chemical and biological analysis.

• Iron chelating activity of agricultural residues
• Isolation and characterization of natural iron chelators
• Comparative evaluation of natural iron chelators with commercially available drugs
• In-vivo investigation of the efficacy of natural iron chelators in iron overloaded rats
• Exploring the potential of natural compounds as a safe and effective alternative to existing iron chelators

Chapter Summaries

• Chapter I: Introduction: This chapter provides an overview of iron disorders in the human body, including the metabolism of iron, iron blood disorders, the classification and causes of iron overload, the complications of iron overload, and existing iron overload medications. It also discusses the potential of natural compounds as alternative chelating agents and highlights the importance of exploring agricultural wastes as a source for biologically active compounds.
• Chapter II: Phytochemical Screening and Iron Chelating Activity of Mangifera indica L. leaves: This chapter focuses on the phytochemical screening and iron chelating activity of mango leaves. It investigates the iron chelating activity of different extracts of mango leaves and analyzes the correlation between iron chelating activity and total flavonoid and phenolic content, as well as antioxidant activity.
• Chapter III: Bio-guided Fractionation of Iron Chelators from Mangifera indica L. leaves: This chapter details the isolation and characterization of iron chelators from mango leaves. It describes the process of bio-guided fractionation and identifies the isolated compounds, including mangiferin and iriflophenone-3-C-ß-D-glucoside.
• Chapter IV: A Comparative Study of the Iron Chelating Property of Mangiferin Vs. Desferal®: This chapter compares the iron chelating properties of mangiferin to a commercially available iron chelator, Desferal®. It explores the chelation pattern of mangiferin and investigates the antioxidant activity of the mangiferin-iron complex compared to the Desferal®-iron complex.

Keywords

This book focuses on natural iron chelators, agricultural wastes, polyphenolic compounds, iron chelation assays, bio-guided fractionation, mangiferin, iriflophenone-3-C-ß-D-glucoside, antioxidant activity, in-vivo studies, iron overload, hemochromatosis, and alternative therapies. It delves into the chemical and biological properties of these compounds and explores their potential as safe and effective alternatives to existing iron chelators.